USE OF POLYOLS TO OBTAIN STABLE POLYMORPHOUS FORMS OF RIFAXIMIN

USE OF POLYOLS TO OBTAIN STABLE POLYMORPHOUS FORMS OF RIFAXIMIN

Polyols stabilize polymorphous form of rifaximin, in particular the ² form. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorph ² is stable and remains stable in time independently from the environment humidity. In this invention a method to prepare formulations...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BOTTONI, Giuseppe, MAFFEI, Paola, VISCOMI, Giuseppe, Claudio, BACHETTI, Milena
Format: Patent
Sprache:eng ; lit
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Polyols stabilize polymorphous form of rifaximin, in particular the ² form. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorph ² is stable and remains stable in time independently from the environment humidity. In this invention a method to prepare formulations constituted by pure and stable polymorphous forms able to give a pharmaceutical product is described.