A SOLUBLE CTLA4 MOLECULE FOR USE IN THE TREATMENT RHEUMATIC DISEASES

The present invention relates to compositions and soluble CTLA4 mutant molecule for use in treatment of rheumatic disease by administering to a subject. Soluble CTLA4 molecules block endogenous B7 molecules from binding their ligands. Šis išradimas yra susijęs su tirpia CTLA4 mutantine molekule ir k...

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Bibliographische Detailangaben
Hauptverfasser:	CARR, SUZETTE S, HAGERTY, DAVID S, PEACH, ROBERT, J. S, COHEN, ROBERT S, BECKER, JEAN, CLAUDE S
Format:	Patent
Sprache:	eng ; lit
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to compositions and soluble CTLA4 mutant molecule for use in treatment of rheumatic disease by administering to a subject. Soluble CTLA4 molecules block endogenous B7 molecules from binding their ligands. Šis išradimas yra susijęs su tirpia CTLA4 mutantine molekule ir kompozicijomis, skirtomis panaudoti reumatinėms ligoms gydyti, skiriant subjektui efektyvų kiekį tirpios CTLA4 mutantinės molekulės, kuri blokuoja endogeninių B7 molekulių susirišimą sujų ligandais.ą