PROCESSES FOR PREPARATION OF CEPHALOSPORN DERIVATIVES

PROCESSES FOR PREPARATION OF CEPHALOSPORN DERIVATIVES

This invention provides systhetic method of cephalosporin derivatives which is stable to beta-lactamese. In solvent such as chlorobenzene, nitrobenzene, nitromethane, etc., 7-[2-(2-aminotiazol-4-yl)-2-(z)-methoxy iminoacetoamido cephalosporin is reacted with 2,3-cyclopentenopyridin in the presence o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LEE, JOON-YONG, SONG, TAE-HEUNG
Format: Patent
Sprache:eng ; kor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:This invention provides systhetic method of cephalosporin derivatives which is stable to beta-lactamese. In solvent such as chlorobenzene, nitrobenzene, nitromethane, etc., 7-[2-(2-aminotiazol-4-yl)-2-(z)-methoxy iminoacetoamido cephalosporin is reacted with 2,3-cyclopentenopyridin in the presence of catalyst such as BF3, diethylether, ZnI2, Al2Cl3 or methanol to yield cephalosporin derivatives of general formula(I). 없음.