PROCESS FOR PREPARING 5-ARYLALKYL-4-ALKOXY-2(5H)-FURANONE DERIVATIVES

The present invention provides 5-arylalkyl-4-alkoxy-2(5H)-furanones of the formula: (I) wherein the oxygen atoms on C-5 and C- alpha , relative to one another, are in the threo-position, with the exclusion of those compounds of the formula (I) wherein R2 is H or CH3 when n=0 or 2, Ro=H, R1=CH3, R3=H...

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Bibliographische Detailangaben
Hauptverfasser:	KLESSING, KLAUS, CHATTERJEE, SHYAM S
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	The present invention provides 5-arylalkyl-4-alkoxy-2(5H)-furanones of the formula: (I) wherein the oxygen atoms on C-5 and C- alpha , relative to one another, are in the threo-position, with the exclusion of those compounds of the formula (I) wherein R2 is H or CH3 when n=0 or 2, Ro=H, R1=CH3, R3=H and R4=H. The present invention also provides processes for their preparation, as well as new 3-alkoxy-5-(subst.)-phenyl-2(E), 4(E)-pentadienoates as reactive intermediates for the preparation of the new furanone derivatives. The new furanone derivatives of the threo series are active as anticonvulsives/anti-epileptics. Therefore, the present invention also provides medicaments which contain these new furanone derivatives, as well as known furanones, the anticonvulsive/anti-epileptic effectiveness of which has been found for the first time.