METHOD AND DERIVATIVE OF CYANO GUANIDINE

METHOD AND DERIVATIVE OF CYANO GUANIDINE

A novel cyanoguanidine derivative represented by the following general formula (I): wherein X stands for a hydrogen atom, a chlorine atom or a bromine atom, and R stands for a lower alkyl group, is an effective precursor for the synthesis of N-cyano-N'-methyl-N''-(2-(5-methyl-4-imidaz...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: ISHITOKU, TAKESHI, KIHARA, NORIAKI, TAKAHASHI, KATSUYA, MUKAIYAMA, TERUAKI
Format: Patent
Sprache:eng ; kor
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A novel cyanoguanidine derivative represented by the following general formula (I): wherein X stands for a hydrogen atom, a chlorine atom or a bromine atom, and R stands for a lower alkyl group, is an effective precursor for the synthesis of N-cyano-N'-methyl-N''-(2-(5-methyl-4-imidazolylmethylthio)ethyl)-guanidin e (Cimetidine) which has an action of controlling secretion of gastric acid and is valuable as an agent for the remedy of a gastric ulcer. This cyanoguanidine derivative is prepared by reacting a methylvinylketone derivative with a mercaptoguanidine derivative or by reacting an amidinoketone derivative with a halogenating agent.