BENZAMIDES

Substituted benzamides of the general formula Iin which:R represents an alkoxy, alkenyloxy or alkynyloxy group containing up to 7 carbon atoms in the group,R, is hydrogen or a NR4R5, or NR6COR7 group, where R4, Rs and R6, which may be the same or different, is each hydrogen or an alkyl group and R7 is an alkyl or trifluoromethyl group,R2 is hydrogen, halogen, or a nitro, or sulphamoyl group,R3 represents hydrogen or a methyl or methoxy group,X represents a hydrocarbon chain containing 1 to 4 carbon atoms, one of which may optionally be replaced by an oxygen atom,Y represents a non-aromatic cyclic ether or a non-aromatic cyclic thioether group and pharmaceutically acceptable salts thereof are useful in the treatment of gastro- intestinal disorders. Various methods of synthesis are described including synthesis via novel amines of the formulawhich are themselves obtained by reduction of the corresponding oximes.