NITROBENZOYL-3-CYCLOPROPYL AMINOACRYLATE AND THERE OF METHOD

NITROBENZOYL-3-CYCLOPROPYL AMINOACRYLATE AND THERE OF METHOD

Nitrobenzoyl-3-cyclopropylaminoacrylates of formula (I) are prepd. by (a) reacting a nitrobenzoylester cpd. of formula (II) with alkylorthoformate in the presence of anhydrous acetic acid to obtain nitrobenzoyl-3-alkoxyacrylate of formula (III), and (b) reacting (III) with cyclopropylamine. In the f...

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Bibliographische Detailangaben
Hauptverfasser: PARK SANG-WOO, KIM YU-SEUNG, KIM JEOL
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Nitrobenzoyl-3-cyclopropylaminoacrylates of formula (I) are prepd. by (a) reacting a nitrobenzoylester cpd. of formula (II) with alkylorthoformate in the presence of anhydrous acetic acid to obtain nitrobenzoyl-3-alkoxyacrylate of formula (III), and (b) reacting (III) with cyclopropylamine. In the formulas, R= methyl, ethyl or propyl; X= Cl, F or Br; R'= ethyl. Cpds. (I) are useful intermediates in the preparation of antibacterial quinolone derivatives.