PROCESS FOR PREPARING 4H-BENZO(4,5)CYCLOHEPTA(1,2-B)THIOPHENE DERIVATIVES
Title compds. (I)[R1=H, C1-4 alkyl, phenyl-(C1-4 alkyl); R2=H, C1-4 alkyl; A ring=substituted halo, OH were prepd. Thus, 200g [10- methoxy-4H-benzo[4,5 cyclohepta[1,2-b thiopen-4-yliden acetate ethyl ester in 0.6l EtOH was refluxed with 1.5M-NaOH at 90 C for 18hr, concd., mixed with ice, and extd. w...
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| creator | BOLLINGER, PIETRO |
| description | Title compds. (I)[R1=H, C1-4 alkyl, phenyl-(C1-4 alkyl); R2=H, C1-4 alkyl; A ring=substituted halo, OH were prepd. Thus, 200g [10- methoxy-4H-benzo[4,5 cyclohepta[1,2-b thiopen-4-yliden acetate ethyl ester in 0.6l EtOH was refluxed with 1.5M-NaOH at 90 C for 18hr, concd., mixed with ice, and extd. with 2 liter ethylether. The ext. was reextracted with 1 liter 1N-NaOH, dissolved in 2 liter ethylene acetate, and adjusted to pH 1.0. Organic layer was separated, washed with ethyl acetate, and dried to give (Z,E) isomer mixt. of [10- methoxy-4H-benzo[4,5 -cyclohepta [1,2-b -thiophen-4-yliden -acetate. |
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Thus, 200g [10- methoxy-4H-benzo[4,5 cyclohepta[1,2-b thiopen-4-yliden acetate ethyl ester in 0.6l EtOH was refluxed with 1.5M-NaOH at 90 C for 18hr, concd., mixed with ice, and extd. with 2 liter ethylether. The ext. was reextracted with 1 liter 1N-NaOH, dissolved in 2 liter ethylene acetate, and adjusted to pH 1.0. Organic layer was separated, washed with ethyl acetate, and dried to give (Z,E) isomer mixt. of [10- methoxy-4H-benzo[4,5 -cyclohepta [1,2-b -thiophen-4-yliden -acetate.</description><edition>4</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1989</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890721&DB=EPODOC&CC=KR&NR=890002638B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890721&DB=EPODOC&CC=KR&NR=890002638B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BOLLINGER, PIETRO</creatorcontrib><title>PROCESS FOR PREPARING 4H-BENZO(4,5)CYCLOHEPTA(1,2-B)THIOPHENE DERIVATIVES</title><description>Title compds. (I)[R1=H, C1-4 alkyl, phenyl-(C1-4 alkyl); R2=H, C1-4 alkyl; A ring=substituted halo, OH were prepd. Thus, 200g [10- methoxy-4H-benzo[4,5 cyclohepta[1,2-b thiopen-4-yliden acetate ethyl ester in 0.6l EtOH was refluxed with 1.5M-NaOH at 90 C for 18hr, concd., mixed with ice, and extd. with 2 liter ethylether. The ext. was reextracted with 1 liter 1N-NaOH, dissolved in 2 liter ethylene acetate, and adjusted to pH 1.0. Organic layer was separated, washed with ethyl acetate, and dried to give (Z,E) isomer mixt. of [10- methoxy-4H-benzo[4,5 -cyclohepta [1,2-b -thiophen-4-yliden -acetate.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1989</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAMCPJ3dg0OVnDzD1IICHINcAzy9HNXMPHQdXL1i_LXMNEx1XSOdPbx93ANCHHUMNQx0nXSDPHw9A_wcPVzVXBxDfIMcwzxDHMN5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8d5BFpYGBgZGZsYWTk6GxsSpAgChoS2c</recordid><startdate>19890721</startdate><enddate>19890721</enddate><creator>BOLLINGER, PIETRO</creator><scope>EVB</scope></search><sort><creationdate>19890721</creationdate><title>PROCESS FOR PREPARING 4H-BENZO(4,5)CYCLOHEPTA(1,2-B)THIOPHENE DERIVATIVES</title><author>BOLLINGER, PIETRO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR890002638BB13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1989</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>BOLLINGER, PIETRO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BOLLINGER, PIETRO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR PREPARING 4H-BENZO(4,5)CYCLOHEPTA(1,2-B)THIOPHENE DERIVATIVES</title><date>1989-07-21</date><risdate>1989</risdate><abstract>Title compds. (I)[R1=H, C1-4 alkyl, phenyl-(C1-4 alkyl); R2=H, C1-4 alkyl; A ring=substituted halo, OH were prepd. Thus, 200g [10- methoxy-4H-benzo[4,5 cyclohepta[1,2-b thiopen-4-yliden acetate ethyl ester in 0.6l EtOH was refluxed with 1.5M-NaOH at 90 C for 18hr, concd., mixed with ice, and extd. with 2 liter ethylether. The ext. was reextracted with 1 liter 1N-NaOH, dissolved in 2 liter ethylene acetate, and adjusted to pH 1.0. Organic layer was separated, washed with ethyl acetate, and dried to give (Z,E) isomer mixt. of [10- methoxy-4H-benzo[4,5 -cyclohepta [1,2-b -thiophen-4-yliden -acetate.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | PROCESS FOR PREPARING 4H-BENZO(4,5)CYCLOHEPTA(1,2-B)THIOPHENE DERIVATIVES |
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