PROCESS FOR PREPARING 4H-BENZO(4,5)CYCLOHEPTA(1,2-B)THIOPHENE DERIVATIVES

PROCESS FOR PREPARING 4H-BENZO(4,5)CYCLOHEPTA(1,2-B)THIOPHENE DERIVATIVES

Title compds. (I)[R1=H, C1-4 alkyl, phenyl-(C1-4 alkyl); R2=H, C1-4 alkyl; A ring=substituted halo, OH were prepd. Thus, 200g [10- methoxy-4H-benzo[4,5 cyclohepta[1,2-b thiopen-4-yliden acetate ethyl ester in 0.6l EtOH was refluxed with 1.5M-NaOH at 90 C for 18hr, concd., mixed with ice, and extd. w...

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Bibliographische Detailangaben
1. Verfasser: BOLLINGER, PIETRO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Title compds. (I)[R1=H, C1-4 alkyl, phenyl-(C1-4 alkyl); R2=H, C1-4 alkyl; A ring=substituted halo, OH were prepd. Thus, 200g [10- methoxy-4H-benzo[4,5 cyclohepta[1,2-b thiopen-4-yliden acetate ethyl ester in 0.6l EtOH was refluxed with 1.5M-NaOH at 90 C for 18hr, concd., mixed with ice, and extd. with 2 liter ethylether. The ext. was reextracted with 1 liter 1N-NaOH, dissolved in 2 liter ethylene acetate, and adjusted to pH 1.0. Organic layer was separated, washed with ethyl acetate, and dried to give (Z,E) isomer mixt. of [10- methoxy-4H-benzo[4,5 -cyclohepta [1,2-b -thiophen-4-yliden -acetate.