METHOD OF COLLETING FAMOTIDINE FROM REACTION LIQUID

METHOD OF COLLETING FAMOTIDINE FROM REACTION LIQUID

A method for recovering famotidine of formula (I) comprises (i) adding water to rxn. liq. (obtd. from the rxn. of 3- (2guanidinothiazol-4-ylmethylthio)propionitrile with sulfamide), (ii) adjusting pH to 8.0-10.0 and sat. with NaCl, (iii) extracting with THF and distg., (iv) filtering and dissolving...

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1. Verfasser: CHUNG YU-SOB
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A method for recovering famotidine of formula (I) comprises (i) adding water to rxn. liq. (obtd. from the rxn. of 3- (2guanidinothiazol-4-ylmethylthio)propionitrile with sulfamide), (ii) adjusting pH to 8.0-10.0 and sat. with NaCl, (iii) extracting with THF and distg., (iv) filtering and dissolving in warm MeOH, and (v) concg. and crystg. (I) is useful for treating hyperacidity.