PROCESS FOR PREPARING N- (2- ((( 5-(DIMETHYLAMINO)-METHYL-2-FURANYL)METHYL)THIO) ETHYL-N-2-NITRO-1,1-ETHENEDIAMINE

Compd. of the formula (I) and their acid-addn. salts were prepd. Thus, a soln. of 198mg CuCl in 25ml acetonitrile was reacted with a soln. of 428mg 2-[[[5-(dimethylamino)methyl- 2 furanyl methyl thio ethaneamine, 296mg 1-methylthio-1-methylamino2- nitroethane, and 200mg TEA in 10ml acetonitrile. The...

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Hauptverfasser:	JANKO ZMITEK, HRIBAR-KIKELJ ALENKA, LAH JOLANDA
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Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	JANKO ZMITEK HRIBAR-KIKELJ ALENKA LAH JOLANDA
description	Compd. of the formula (I) and their acid-addn. salts were prepd. Thus, a soln. of 198mg CuCl in 25ml acetonitrile was reacted with a soln. of 428mg 2-[[[5-(dimethylamino)methyl- 2 furanyl methyl thio ethaneamine, 296mg 1-methylthio-1-methylamino2- nitroethane, and 200mg TEA in 10ml acetonitrile. The resulting ppt. was filtered and removed. The filtrate was mixed with 30ml chloroform and extd. with 20ml ammonia water 3 times. The organic phase was dried on Na2SO4, filtered, and vaporized to give (I)(yield, 94%). Compd. I inhibits the secretion of gastric acid stimulated by histamine-H2-acceptor.
format	Patent
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Thus, a soln. of 198mg CuCl in 25ml acetonitrile was reacted with a soln. of 428mg 2-[[[5-(dimethylamino)methyl- 2 furanyl methyl thio ethaneamine, 296mg 1-methylthio-1-methylamino2- nitroethane, and 200mg TEA in 10ml acetonitrile. The resulting ppt. was filtered and removed. The filtrate was mixed with 30ml chloroform and extd. with 20ml ammonia water 3 times. The organic phase was dried on Na2SO4, filtered, and vaporized to give (I)(yield, 94%). Compd. I inhibits the secretion of gastric acid stimulated by histamine-H2-acceptor.</description><edition>4</edition><language>eng ; kor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1987</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870213&DB=EPODOC&CC=KR&NR=870000165B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870213&DB=EPODOC&CC=KR&NR=870000165B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JANKO ZMITEK</creatorcontrib><creatorcontrib>HRIBAR-KIKELJ ALENKA</creatorcontrib><creatorcontrib>LAH JOLANDA</creatorcontrib><title>PROCESS FOR PREPARING N- (2- ((( 5-(DIMETHYLAMINO)-METHYL-2-FURANYL)METHYL)THIO) ETHYL-N-2-NITRO-1,1-ETHENEDIAMINE</title><description>Compd. of the formula (I) and their acid-addn. salts were prepd. 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Thus, a soln. of 198mg CuCl in 25ml acetonitrile was reacted with a soln. of 428mg 2-[[[5-(dimethylamino)methyl- 2 furanyl methyl thio ethaneamine, 296mg 1-methylthio-1-methylamino2- nitroethane, and 200mg TEA in 10ml acetonitrile. The resulting ppt. was filtered and removed. The filtrate was mixed with 30ml chloroform and extd. with 20ml ammonia water 3 times. The organic phase was dried on Na2SO4, filtered, and vaporized to give (I)(yield, 94%). Compd. I inhibits the secretion of gastric acid stimulated by histamine-H2-acceptor.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	PROCESS FOR PREPARING N- (2- ((( 5-(DIMETHYLAMINO)-METHYL-2-FURANYL)METHYL)THIO) ETHYL-N-2-NITRO-1,1-ETHENEDIAMINE
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