PROCESS FOR PREPARING N- (2- ((( 5-(DIMETHYLAMINO)-METHYL-2-FURANYL)METHYL)THIO) ETHYL-N-2-NITRO-1,1-ETHENEDIAMINE

PROCESS FOR PREPARING N- (2- ((( 5-(DIMETHYLAMINO)-METHYL-2-FURANYL)METHYL)THIO) ETHYL-N-2-NITRO-1,1-ETHENEDIAMINE

Compd. of the formula (I) and their acid-addn. salts were prepd. Thus, a soln. of 198mg CuCl in 25ml acetonitrile was reacted with a soln. of 428mg 2-[[[5-(dimethylamino)methyl- 2 furanyl methyl thio ethaneamine, 296mg 1-methylthio-1-methylamino2- nitroethane, and 200mg TEA in 10ml acetonitrile. The...

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Bibliographische Detailangaben
Hauptverfasser: JANKO ZMITEK, HRIBAR-KIKELJ ALENKA, LAH JOLANDA
Format: Patent
Sprache:eng ; kor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compd. of the formula (I) and their acid-addn. salts were prepd. Thus, a soln. of 198mg CuCl in 25ml acetonitrile was reacted with a soln. of 428mg 2-[[[5-(dimethylamino)methyl- 2 furanyl methyl thio ethaneamine, 296mg 1-methylthio-1-methylamino2- nitroethane, and 200mg TEA in 10ml acetonitrile. The resulting ppt. was filtered and removed. The filtrate was mixed with 30ml chloroform and extd. with 20ml ammonia water 3 times. The organic phase was dried on Na2SO4, filtered, and vaporized to give (I)(yield, 94%). Compd. I inhibits the secretion of gastric acid stimulated by histamine-H2-acceptor.