A PROCESS FOR PRODUCING COMPOSITION FORLONG ACTING NICARDIPINE PREPARATION

A PROCESS FOR PRODUCING COMPOSITION FORLONG ACTING NICARDIPINE PREPARATION

Long acting nicardipine (I) or its salt was prepd. by coating nicardipine(salt) and pH-dependent additive on small particle cores, Nonpareil 103. Thus, 728.6g Nonpareil was spray-coated with 1.2 kg soln. of 80g I, 80g hydroxypropyl methylcellulose phthalate HP55 and 20g Tween 80 in 1:1 MeOH-C2H2 to...

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Hauptverfasser: ARUGA MASAYOSHI, KUBOTA YUKIO, SANOBE TAKASHI, YONEA SATORU, KAWATA HIROICHU, OMURA TADAYOSHI
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator ARUGA MASAYOSHI
KUBOTA YUKIO
SANOBE TAKASHI
YONEA SATORU
KAWATA HIROICHU
OMURA TADAYOSHI
description Long acting nicardipine (I) or its salt was prepd. by coating nicardipine(salt) and pH-dependent additive on small particle cores, Nonpareil 103. Thus, 728.6g Nonpareil was spray-coated with 1.2 kg soln. of 80g I, 80g hydroxypropyl methylcellulose phthalate HP55 and 20g Tween 80 in 1:1 MeOH-C2H2 to give globular granules. The granule was dried for 4hr at 40 C and capsulated to form capsulated prepns. (I) is useful in treatment of disturbance of the cerebral blood vessel, hypertension and angina pectoris.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title A PROCESS FOR PRODUCING COMPOSITION FORLONG ACTING NICARDIPINE PREPARATION
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