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Penems I (R=H, lower alkyl, 2,2,2-trichloroalkyl, benzyl, acetonyl, p-nitrobenzyl, p-methoxybenzyl, Ph, p-nitro-Ph, benzhydryl, acetoxymethyl, Me-CH-OCO2Et, CH2NHCOR2; R2=C1-C5 alkyl, aryl; Z=H, halo, OH, amino, carbamoyloxy, mercapto, pyridinium, OR3, OCOR3, NHCOR3, SR4; R3, R4 independently=lower...

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Bibliographische Detailangaben
Hauptverfasser:	FOGLIO MAURIZIO, SANFILIPPO AURORA, ARCAMONE FEDERICO, SCARAFILE COSIMO, FRANCESCHI GIOVANNI
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Penems I (R=H, lower alkyl, 2,2,2-trichloroalkyl, benzyl, acetonyl, p-nitrobenzyl, p-methoxybenzyl, Ph, p-nitro-Ph, benzhydryl, acetoxymethyl, Me-CH-OCO2Et, CH2NHCOR2; R2=C1-C5 alkyl, aryl; Z=H, halo, OH, amino, carbamoyloxy, mercapto, pyridinium, OR3, OCOR3, NHCOR3, SR4; R3, R4 independently=lower alkyl, aryl, heterocyclic ring; n=0, 1) were prepd. Thus, 2.0g methylpenicillinate S-oxide in 40mL toluene and 2.8g butandiol diacetate were refluxed for 24 hrs. to give 1.4g 4β-vinylthio - [1,2-diacetoxymethyl - 1 - [methoxycarbonyl-2-methyl-2-propenyl - azetidine-2-on-S-oxide.