PROCESS FOR PREPARING CEPHALOSPORINE DESACETOXY ESTERS

PROCESS FOR PREPARING CEPHALOSPORINE DESACETOXY ESTERS

The title compds.[I; R=C6H5-, C6H5OH; R1=CH2-OCOC(CH3)3, etc. were prepd. as antibiotics. Thus, 101g Et3N was added dropwise over 3 hr to 214g 7-ADCA, 213g bromophthalide, and 2000mL dimethylformamide. The resulting mixt. was stirred at 35oC for 2 hr, cooled to 0oC, diluted with 4000mL H2O, adjusted...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BROGGI RENATO, FALCIANI MARCO
Format: Patent
Sprache:eng ; kor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The title compds.[I; R=C6H5-, C6H5OH; R1=CH2-OCOC(CH3)3, etc. were prepd. as antibiotics. Thus, 101g Et3N was added dropwise over 3 hr to 214g 7-ADCA, 213g bromophthalide, and 2000mL dimethylformamide. The resulting mixt. was stirred at 35oC for 2 hr, cooled to 0oC, diluted with 4000mL H2O, adjusted to pH 1.0 with 37% HCl, treated with CH2Cl2, and extd. with 1000mL CH2Cl2 to give 190g phthalide ester chlorohydrate of 7-ADCA.