PROCESS FOR PREPARING CEPHALOSPORIN COMPOUNDS

Celphalosporins (II, R1 = protected aminl; R2 = H, protective group; R3 = H, lower alkyl, alkylthio, alkoxy; Z = S) were prepd. by hydrolysis of III. Thus, 0.35 g (6R, 7R)-3-phosphono-carbamoyloxy-methyl-7- Z-2-(fur-2-yl)-2-methoxy-imino-acetamido ceph-3-em-4-carboxylic acid was treated at 40 C for...

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Hauptverfasser: LAING STUART BRUCE, HUMBER DAVID CEDRIC, WEINGARTEN GORDON GAD
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creator LAING STUART BRUCE
HUMBER DAVID CEDRIC
WEINGARTEN GORDON GAD
description Celphalosporins (II, R1 = protected aminl; R2 = H, protective group; R3 = H, lower alkyl, alkylthio, alkoxy; Z = S) were prepd. by hydrolysis of III. Thus, 0.35 g (6R, 7R)-3-phosphono-carbamoyloxy-methyl-7- Z-2-(fur-2-yl)-2-methoxy-imino-acetamido ceph-3-em-4-carboxylic acid was treated at 40 C for 5 hr, room temp 16 hr, 40 C 6 hr, 20 C 16 hr in the mixed solution of 4 ml H2O and 1 ml dioxane to give (6R, 7R)-3-carbamoyloxymethyl-7- Z-2-(fur-2-yl)-2-methoxy-iminoacetamido ceph-3-em-4-carboxylic acid.
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS
GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC
GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
title PROCESS FOR PREPARING CEPHALOSPORIN COMPOUNDS
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