PROCESS FOR PREPARING CEPHALOSPORIN COMPOUNDS

Celphalosporins (II, R1 = protected aminl; R2 = H, protective group; R3 = H, lower alkyl, alkylthio, alkoxy; Z = S) were prepd. by hydrolysis of III. Thus, 0.35 g (6R, 7R)-3-phosphono-carbamoyloxy-methyl-7- Z-2-(fur-2-yl)-2-methoxy-imino-acetamido ceph-3-em-4-carboxylic acid was treated at 40 C for...

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Hauptverfasser:	LAING STUART BRUCE, HUMBER DAVID CEDRIC, WEINGARTEN GORDON GAD
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	Celphalosporins (II, R1 = protected aminl; R2 = H, protective group; R3 = H, lower alkyl, alkylthio, alkoxy; Z = S) were prepd. by hydrolysis of III. Thus, 0.35 g (6R, 7R)-3-phosphono-carbamoyloxy-methyl-7- Z-2-(fur-2-yl)-2-methoxy-imino-acetamido ceph-3-em-4-carboxylic acid was treated at 40 C for 5 hr, room temp 16 hr, 40 C 6 hr, 20 C 16 hr in the mixed solution of 4 ml H2O and 1 ml dioxane to give (6R, 7R)-3-carbamoyloxymethyl-7- Z-2-(fur-2-yl)-2-methoxy-iminoacetamido ceph-3-em-4-carboxylic acid.