PROCESS FOR PREPARING N-OXACYCLIC-ALKYLPIPERIDYL-DIAZA COMPOUNDS

PROCESS FOR PREPARING N-OXACYCLIC-ALKYLPIPERIDYL-DIAZA COMPOUNDS

Title compds. (I; Ph = subatituted 1,2-phenylene; R1, R2, R3, R4, = H, lower alkyl; R5 = H, olwer alkyl, HPh; X = oxo, thioxo, imino, lower alkylimino; Y = epoxy, epithio, sulftinyl; m = 1-7; p,q = 1-3; p+q = 4), having antidepressive activity, were prepd. by condensation of III(Z = esterified hydro...

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Bibliographische Detailangaben
1. Verfasser: HUEBNER CHARLES FERDINAND
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Title compds. (I; Ph = subatituted 1,2-phenylene; R1, R2, R3, R4, = H, lower alkyl; R5 = H, olwer alkyl, HPh; X = oxo, thioxo, imino, lower alkylimino; Y = epoxy, epithio, sulftinyl; m = 1-7; p,q = 1-3; p+q = 4), having antidepressive activity, were prepd. by condensation of III(Z = esterified hydroxy) with IV. Thus, a mixt. of 4.9 g 2-(2-tosyloxyethyl)-1, 4-benzodioxane, 2.54 g 1-(4-piperidyl)-2-imidazolidinone, 5 g anhyd. Na2 CO3, 100 ml 4-methyl-2-pentanone was refluxed for 3 days to give'1- 1- 2-(1,4-benzodioxan-2-yl)-ethyl -4-piperidinyl -2-imidazolinone(m.p. 125 C).