PROCESS FOR PREPARING COMPOSITION OF SOLID MEDICINE FORM CONTAINING NIPEDIPINE

Solid forms of nifedipine (I), which have higher bioavailability and lower volume, are prepd. by dissolving or suspending I in a solvent with an appropriate solids (polyvinylpyrrolidinone, methyl cellulose, hydroxy propyl cellulose, etc.) and removing the solvent. Thus, 1 g nifedipine, 2 g poly vinylpyrrolidinone and 1 g Na lauryl sulfate were dissolved in 60 g CHCH3-EtOH (9:1). Spray-drying gave a powder which, on oral administration to dogs, yielded plasma I concns. comparable with those given by a std. I prepn.