PROCESS FOR THE PREPARATION OF N-(2-SUBSTITUTE-ETHYL-1)-3-BENZOYL PROPION AMIDE

PROCESS FOR THE PREPARATION OF N-(2-SUBSTITUTE-ETHYL-1)-3-BENZOYL PROPION AMIDE

Title compds. [I, R = H, halogen, lower alky1; X = O, S,: N-R1 (R1 = lower alky1) , useful as cholesterol-lowering agent, were prepd. by reacting II with mixed acid anhydride of benzoy1 propionic acid and chloroethy1 carbonate. Thus, 17.8 g 3-benzoy1 propionic acid, 10.1 g triethy1 amine and 10.85 g...

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Hauptverfasser: SEDO EISUKE, MORIDA IWAO, KISE MASAHIRO
Format: Patent
Sprache:eng
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Zusammenfassung:Title compds. [I, R = H, halogen, lower alky1; X = O, S,: N-R1 (R1 = lower alky1) , useful as cholesterol-lowering agent, were prepd. by reacting II with mixed acid anhydride of benzoy1 propionic acid and chloroethy1 carbonate. Thus, 17.8 g 3-benzoy1 propionic acid, 10.1 g triethy1 amine and 10.85 g chloroethy1 carbonate dissolved in chloroform were stirred with 15.0 g 2-(N-methy1 anilino)ethy1 amine to give 25 g N-[2-(N-ethy1 aniline)ethy1 -3-benzoy1 propion amide.