PROCESS FOR THE PREPARATION OF BENZAMIDE DERIVATIVES

PROCESS FOR THE PREPARATION OF BENZAMIDE DERIVATIVES

Benzeamide derivs. (I; X,Y = H, lower alky1, lower aolkxy ; a =lower alkylene ; R1,R2 = lower alky1), having antiulcer activity, were prepd. by the reaction of II with III at -10-150 C in inactive solvent such as THF, dioxane, isopropylalcohol, MeOH, EtoH, toluene, benzene, pyridine, DMF, etc. for 0...

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Hauptverfasser: FURUNO KOUJI, MORI TAKASHI, OOI NOBUHIRO, SHINDO MINORU, TAKAKU SAKAE, HIRANO TAKEAKI
Format: Patent
Sprache:eng
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Zusammenfassung:Benzeamide derivs. (I; X,Y = H, lower alky1, lower aolkxy ; a =lower alkylene ; R1,R2 = lower alky1), having antiulcer activity, were prepd. by the reaction of II with III at -10-150 C in inactive solvent such as THF, dioxane, isopropylalcohol, MeOH, EtoH, toluene, benzene, pyridine, DMF, etc. for 0.5-10hr. II was obtained by the reaction of 2,4-diamino benzoic acid with reactive derivs. of benzoic acid having X,Y as substitution group.