IMPROVEMENT OF PENICILIN PREPARATION
α-Aminoacylpenicillins were manufd. from 6-aminopenicillanic acid (6-APA) by a modified method. The suspension of 6-APA in chlorinated hydrocarbon solvent contg. PH 10 tri(low alkyl) amine was dissolved by stirring for 1hr at 25 C and neutralized with N,N-dimethylacetamide HCl at 0 C. The neutralize...
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| Zusammenfassung: | α-Aminoacylpenicillins were manufd. from 6-aminopenicillanic acid (6-APA) by a modified method. The suspension of 6-APA in chlorinated hydrocarbon solvent contg. PH 10 tri(low alkyl) amine was dissolved by stirring for 1hr at 25 C and neutralized with N,N-dimethylacetamide HCl at 0 C. The neutralized soln. was contacted to org. solvent dissolving the anhydride mix. of low alkoxy formic acid and N-protected deriv. of amino acid to give α-aminoacylpenicillins. |
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