PROCESS FOR PREPERATION OF 1,3,5 TRISUSTITUTED BENZENES

PROCESS FOR PREPERATION OF 1,3,5 TRISUSTITUTED BENZENES

1,3,5-Trisubstituted benzene derivs. I(R1 = lower alkyl, cyclohexyl, phenyl, phenyl substituted as alkyl, alkoxy, or halogen, R2 = H, C1-C5 alkyl), useful as antiimflammatory agent and analgesics, were prepd. by reducing II (R3 = lower alkyl). For example, II (R1 = R2 = R3 = Me) in Et2O was added to...

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Hauptverfasser: YOSHIMOTO YOSHIHIKO, MURAI HITOMU, KURIMOTO KATSUTOSHI, MURAYAMA MASAO, OOHATA KATSUYA
Format: Patent
Sprache:eng
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Zusammenfassung:1,3,5-Trisubstituted benzene derivs. I(R1 = lower alkyl, cyclohexyl, phenyl, phenyl substituted as alkyl, alkoxy, or halogen, R2 = H, C1-C5 alkyl), useful as antiimflammatory agent and analgesics, were prepd. by reducing II (R3 = lower alkyl). For example, II (R1 = R2 = R3 = Me) in Et2O was added to 2.2g LiAlH4 in Et2O at 20-25 C and the mixt. stirred for 1hr at room temp. to give 55% I (R1 = R2 = Me).