METHOD FOR PREPARING NOVEL GUANAMIDE DERIVATIVES

METHOD FOR PREPARING NOVEL GUANAMIDE DERIVATIVES

Guanamides (II ; R = halogenophenyl), nitrophenyl, lower alkylphenyl or pyridyl), which are useful as antiinflammatory and antiulcer, were prepd. by reaction of aromatic derivs. (I ; R = halogenophenyl, nitrophenyl, lower alkylphenyl or pyridyl, Z = lower alkoxy or amino) with biuret in the presence...

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Bibliographische Detailangaben
Hauptverfasser: MURAI HIROMU, AOYAKI YOSHIAKI
Format: Patent
Sprache:eng
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Zusammenfassung:Guanamides (II ; R = halogenophenyl), nitrophenyl, lower alkylphenyl or pyridyl), which are useful as antiinflammatory and antiulcer, were prepd. by reaction of aromatic derivs. (I ; R = halogenophenyl, nitrophenyl, lower alkylphenyl or pyridyl, Z = lower alkoxy or amino) with biuret in the presence of alk. catalyst. Thus, II were prepd. by refluxing Na metal and benzoic ester or nicotinic ester in MeOH and acidifying the resultant products.