Cell culture substrate for Osteogenic differentiation and method for manufacturing thereof
골세포 분화 촉진용 세포배양기재가 제공된다. 본 발명의 일 실시예에 의한 세포배양기재는 섬유웹, 및 상기 섬유웹 표면의 적어도 일부를 피복하며, 골세포 분화용 펩타이드 및 부착용 펩타이드를 포함하는 융합 폴리펩타이드를 구비한 골세포 분화 촉진층을 포함한다. 이에 의하면, 조골세포의 부착성을 증가시켜서 세포 배양 및 분화 중 발생하는 세포배양액의 흐름 등 흔들림에도 부착된 세포의 탈리를 최소화 또는 방지할 수 있다. 또한, 조골세포의 증식성을 개선시키며, 골세포로의 뛰어난 분화효율을 달성할 수 있음에 따라서 골조직 재건 및 재생에 널...
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| description | 골세포 분화 촉진용 세포배양기재가 제공된다. 본 발명의 일 실시예에 의한 세포배양기재는 섬유웹, 및 상기 섬유웹 표면의 적어도 일부를 피복하며, 골세포 분화용 펩타이드 및 부착용 펩타이드를 포함하는 융합 폴리펩타이드를 구비한 골세포 분화 촉진층을 포함한다. 이에 의하면, 조골세포의 부착성을 증가시켜서 세포 배양 및 분화 중 발생하는 세포배양액의 흐름 등 흔들림에도 부착된 세포의 탈리를 최소화 또는 방지할 수 있다. 또한, 조골세포의 증식성을 개선시키며, 골세포로의 뛰어난 분화효율을 달성할 수 있음에 따라서 골조직 재건 및 재생에 널리 응용될 수 있다.
Provided is a cell culture substrate for promoting osteocyte differentiation. In one embodiment of the present invention, the cell culture substrate includes a fiber web and an osteoblast differentiation-promoting layer that is applied to at least a portion of the surface of the fiber web and which comprises a fusion polypeptide including a peptide for osteocyte differentiation and a peptide for attachment. According to the cell culture substrate, the adhesion of osteoblasts can be improved to minimize or prevent the detachment of attached cells in spite of shaking, such as the flow of cell culture medium, which may take place during cell culture and differentiation. In addition, the cell culture substrate improves the proliferation of osteoblasts and achieves high differentiation efficiency into osteocytes, thus finding wide applications in bone tissue reconstruction and regeneration. |
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Provided is a cell culture substrate for promoting osteocyte differentiation. In one embodiment of the present invention, the cell culture substrate includes a fiber web and an osteoblast differentiation-promoting layer that is applied to at least a portion of the surface of the fiber web and which comprises a fusion polypeptide including a peptide for osteocyte differentiation and a peptide for attachment. According to the cell culture substrate, the adhesion of osteoblasts can be improved to minimize or prevent the detachment of attached cells in spite of shaking, such as the flow of cell culture medium, which may take place during cell culture and differentiation. In addition, the cell culture substrate improves the proliferation of osteoblasts and achieves high differentiation efficiency into osteocytes, thus finding wide applications in bone tissue reconstruction and regeneration.</description><language>eng ; kor</language><subject>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY ; BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241002&DB=EPODOC&CC=KR&NR=20240142627A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241002&DB=EPODOC&CC=KR&NR=20240142627A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>IN CHI UK</creatorcontrib><creatorcontrib>SEO DONG SIK</creatorcontrib><title>Cell culture substrate for Osteogenic differentiation and method for manufacturing thereof</title><description>골세포 분화 촉진용 세포배양기재가 제공된다. 본 발명의 일 실시예에 의한 세포배양기재는 섬유웹, 및 상기 섬유웹 표면의 적어도 일부를 피복하며, 골세포 분화용 펩타이드 및 부착용 펩타이드를 포함하는 융합 폴리펩타이드를 구비한 골세포 분화 촉진층을 포함한다. 이에 의하면, 조골세포의 부착성을 증가시켜서 세포 배양 및 분화 중 발생하는 세포배양액의 흐름 등 흔들림에도 부착된 세포의 탈리를 최소화 또는 방지할 수 있다. 또한, 조골세포의 증식성을 개선시키며, 골세포로의 뛰어난 분화효율을 달성할 수 있음에 따라서 골조직 재건 및 재생에 널리 응용될 수 있다.
Provided is a cell culture substrate for promoting osteocyte differentiation. In one embodiment of the present invention, the cell culture substrate includes a fiber web and an osteoblast differentiation-promoting layer that is applied to at least a portion of the surface of the fiber web and which comprises a fusion polypeptide including a peptide for osteocyte differentiation and a peptide for attachment. According to the cell culture substrate, the adhesion of osteoblasts can be improved to minimize or prevent the detachment of attached cells in spite of shaking, such as the flow of cell culture medium, which may take place during cell culture and differentiation. In addition, the cell culture substrate improves the proliferation of osteoblasts and achieves high differentiation efficiency into osteocytes, thus finding wide applications in bone tissue reconstruction and regeneration.</description><subject>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzLEKwjAQgOEsDqK-w4GzUGOxsxRFcBDEyaWcyaUNpJeSXN7fIj6A0798_Ev1aikEMCVISQS5vLMkFAIXE9yzUOyJvQHrnaNELB7FRwZkCyPJEO1XjsjFoZkfnnuQYabRrdXCYci0-XWltpfzs73uaIod5QkNMUl3e-hK19W-1kfdnA7_qQ9y7Tyo</recordid><startdate>20241002</startdate><enddate>20241002</enddate><creator>IN CHI UK</creator><creator>SEO DONG SIK</creator><scope>EVB</scope></search><sort><creationdate>20241002</creationdate><title>Cell culture substrate for Osteogenic differentiation and method for manufacturing thereof</title><author>IN CHI UK ; SEO DONG SIK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20240142627A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2024</creationdate><topic>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>IN CHI UK</creatorcontrib><creatorcontrib>SEO DONG SIK</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>IN CHI UK</au><au>SEO DONG SIK</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Cell culture substrate for Osteogenic differentiation and method for manufacturing thereof</title><date>2024-10-02</date><risdate>2024</risdate><abstract>골세포 분화 촉진용 세포배양기재가 제공된다. 본 발명의 일 실시예에 의한 세포배양기재는 섬유웹, 및 상기 섬유웹 표면의 적어도 일부를 피복하며, 골세포 분화용 펩타이드 및 부착용 펩타이드를 포함하는 융합 폴리펩타이드를 구비한 골세포 분화 촉진층을 포함한다. 이에 의하면, 조골세포의 부착성을 증가시켜서 세포 배양 및 분화 중 발생하는 세포배양액의 흐름 등 흔들림에도 부착된 세포의 탈리를 최소화 또는 방지할 수 있다. 또한, 조골세포의 증식성을 개선시키며, 골세포로의 뛰어난 분화효율을 달성할 수 있음에 따라서 골조직 재건 및 재생에 널리 응용될 수 있다.
Provided is a cell culture substrate for promoting osteocyte differentiation. In one embodiment of the present invention, the cell culture substrate includes a fiber web and an osteoblast differentiation-promoting layer that is applied to at least a portion of the surface of the fiber web and which comprises a fusion polypeptide including a peptide for osteocyte differentiation and a peptide for attachment. According to the cell culture substrate, the adhesion of osteoblasts can be improved to minimize or prevent the detachment of attached cells in spite of shaking, such as the flow of cell culture medium, which may take place during cell culture and differentiation. In addition, the cell culture substrate improves the proliferation of osteoblasts and achieves high differentiation efficiency into osteocytes, thus finding wide applications in bone tissue reconstruction and regeneration.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Cell culture substrate for Osteogenic differentiation and method for manufacturing thereof |
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