Microspheres containing high-dose varenicline method for preparing the same and pharmaceutical composition comprising the same
본 발명은 바레니클린 헤미파모에이트, 및 생체적합성 고분자를 포함하는 미립구 및 이의 제조방법 및 이를 포함하는 약학 조성물에 관한 것이다. 본 발명에 따른 바레니클린을 포함하는 미립구는 바레니클린이 고농도로 봉입되고, 장기간 동안 안정한 약물 방출률을 나타내며, 적정한 초기 방출률을 나타내어, 부작용 없이 일정 기간 동안 혈액 내에 바레니클린을 유효 농도로 유지시킬 수 있다. The present invention relates to microspheres comprising varenicline hemipamoate and a...
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| creator | KIM A RAM LEE GI SUN AN TAE KUN SHIN HYEON HO PARK JIN PARK YU RI KIM CHERNG JU |
| description | 본 발명은 바레니클린 헤미파모에이트, 및 생체적합성 고분자를 포함하는 미립구 및 이의 제조방법 및 이를 포함하는 약학 조성물에 관한 것이다. 본 발명에 따른 바레니클린을 포함하는 미립구는 바레니클린이 고농도로 봉입되고, 장기간 동안 안정한 약물 방출률을 나타내며, 적정한 초기 방출률을 나타내어, 부작용 없이 일정 기간 동안 혈액 내에 바레니클린을 유효 농도로 유지시킬 수 있다.
The present invention relates to microspheres comprising varenicline hemipamoate and a biocompatible polymer, a method for preparing same, and a pharmaceutical composition comprising same. The microspheres comprising varenicline, according to the present invention, encapsulate a high concentration of varenicline, and exhibit a stable drug release rate over a long period of time and an appropriate initial release rate, and thus can maintain varenicline at an effective concentration in the blood for a certain period of time without side effects. |
| format | Patent |
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The present invention relates to microspheres comprising varenicline hemipamoate and a biocompatible polymer, a method for preparing same, and a pharmaceutical composition comprising same. The microspheres comprising varenicline, according to the present invention, encapsulate a high concentration of varenicline, and exhibit a stable drug release rate over a long period of time and an appropriate initial release rate, and thus can maintain varenicline at an effective concentration in the blood for a certain period of time without side effects.</description><language>eng ; kor</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240725&DB=EPODOC&CC=KR&NR=20240115109A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240725&DB=EPODOC&CC=KR&NR=20240115109A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KIM A RAM</creatorcontrib><creatorcontrib>LEE GI SUN</creatorcontrib><creatorcontrib>AN TAE KUN</creatorcontrib><creatorcontrib>SHIN HYEON HO</creatorcontrib><creatorcontrib>PARK JIN</creatorcontrib><creatorcontrib>PARK YU RI</creatorcontrib><creatorcontrib>KIM CHERNG JU</creatorcontrib><title>Microspheres containing high-dose varenicline method for preparing the same and pharmaceutical composition comprising the same</title><description>본 발명은 바레니클린 헤미파모에이트, 및 생체적합성 고분자를 포함하는 미립구 및 이의 제조방법 및 이를 포함하는 약학 조성물에 관한 것이다. 본 발명에 따른 바레니클린을 포함하는 미립구는 바레니클린이 고농도로 봉입되고, 장기간 동안 안정한 약물 방출률을 나타내며, 적정한 초기 방출률을 나타내어, 부작용 없이 일정 기간 동안 혈액 내에 바레니클린을 유효 농도로 유지시킬 수 있다.
The present invention relates to microspheres comprising varenicline hemipamoate and a biocompatible polymer, a method for preparing same, and a pharmaceutical composition comprising same. The microspheres comprising varenicline, according to the present invention, encapsulate a high concentration of varenicline, and exhibit a stable drug release rate over a long period of time and an appropriate initial release rate, and thus can maintain varenicline at an effective concentration in the blood for a certain period of time without side effects.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLEKwkAQBdNYiPoPC9aBJGphKaIIYiP2YblscgvJ3rF7WvrtRrGwtHqvmJlp9ryw02DRk5KBC5KQhaUDz53Pm2AED1QSdj0LwUDJhwbaoBCVIuobTZ7AcCBAaSB61AEd3RM77MfiEINx4iCfr2y_yjybtNgbLb47y5bHw21_yimGmiyOIaFUn69VUa2LstyUxXa3-o96AV6rSlw</recordid><startdate>20240725</startdate><enddate>20240725</enddate><creator>KIM A RAM</creator><creator>LEE GI SUN</creator><creator>AN TAE KUN</creator><creator>SHIN HYEON HO</creator><creator>PARK JIN</creator><creator>PARK YU RI</creator><creator>KIM CHERNG JU</creator><scope>EVB</scope></search><sort><creationdate>20240725</creationdate><title>Microspheres containing high-dose varenicline method for preparing the same and pharmaceutical composition comprising the same</title><author>KIM A RAM ; LEE GI SUN ; AN TAE KUN ; SHIN HYEON HO ; PARK JIN ; PARK YU RI ; KIM CHERNG JU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20240115109A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2024</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KIM A RAM</creatorcontrib><creatorcontrib>LEE GI SUN</creatorcontrib><creatorcontrib>AN TAE KUN</creatorcontrib><creatorcontrib>SHIN HYEON HO</creatorcontrib><creatorcontrib>PARK JIN</creatorcontrib><creatorcontrib>PARK YU RI</creatorcontrib><creatorcontrib>KIM CHERNG JU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KIM A RAM</au><au>LEE GI SUN</au><au>AN TAE KUN</au><au>SHIN HYEON HO</au><au>PARK JIN</au><au>PARK YU RI</au><au>KIM CHERNG JU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Microspheres containing high-dose varenicline method for preparing the same and pharmaceutical composition comprising the same</title><date>2024-07-25</date><risdate>2024</risdate><abstract>본 발명은 바레니클린 헤미파모에이트, 및 생체적합성 고분자를 포함하는 미립구 및 이의 제조방법 및 이를 포함하는 약학 조성물에 관한 것이다. 본 발명에 따른 바레니클린을 포함하는 미립구는 바레니클린이 고농도로 봉입되고, 장기간 동안 안정한 약물 방출률을 나타내며, 적정한 초기 방출률을 나타내어, 부작용 없이 일정 기간 동안 혈액 내에 바레니클린을 유효 농도로 유지시킬 수 있다.
The present invention relates to microspheres comprising varenicline hemipamoate and a biocompatible polymer, a method for preparing same, and a pharmaceutical composition comprising same. The microspheres comprising varenicline, according to the present invention, encapsulate a high concentration of varenicline, and exhibit a stable drug release rate over a long period of time and an appropriate initial release rate, and thus can maintain varenicline at an effective concentration in the blood for a certain period of time without side effects.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Microspheres containing high-dose varenicline method for preparing the same and pharmaceutical composition comprising the same |
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