E3 Novel E3 ligase ligand and uses thereof

The present invention relates to a novel E3 ligase ligand, and more specifically, to a protein degradation target chimera; a composition for degrading a target protein comprising the protein degradation target chimera; and a pharmaceutical composition for preventing or treating a neurodegenerative d...

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Bibliographische Detailangaben
Hauptverfasser:	PARK KYOUNG RYOUNG, KOH EUN YOUNG, WOO SANG HYEOK, KWAK YUN MI, KANG HO YOUNG
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a novel E3 ligase ligand, and more specifically, to a protein degradation target chimera; a composition for degrading a target protein comprising the protein degradation target chimera; and a pharmaceutical composition for preventing or treating a neurodegenerative disease. It was experimentally confirmed that the protein degradation target chimera comprising the novel E3 ligase ligand and its mutant according to the present invention has excellent target protein degradation efficacy. Therefore, the E3 ligase ligand and its mutant of the present invention may be utilized in various fields in research fields related to the target protein degradation; and in fields of disease treatment through the target protein degradation. 본 발명은 신규한 E3 리가아제 리간드에 관한 것으로, 더욱 상세하게는 단백질 분해 표적 키메라; 상기 단백질 분해 표적 키메라를 포함하는 목적 단백질 분해용 조성물; 및 신경 퇴행성 질환 예방 또는 치료용 약학적 조성물;에 관한 것이다. 본 발명에 따른 신규한 E3 리가아제 리간드 및 이의 돌연변이체를 포함하는 단백질 분해 표적 키메라는 목적 단백질 분해 효능이 우수한 것을 실험적으로 확인하였다. 따라서 본 발명의 E3 리가아제 리간드 및 이의 돌연변이체는 목적 단백질 분해 관련 연구 분야; 및 목적 단백질 분해를 통한 질환 치료 분야;에서 다양하게 활용될 수 있다.