Composition for preventing ameliorationg or treating asthma comprising Malus baccata var. mandshurica extract as effective component

The present invention relates to a composition for preventing, alleviating or treating asthma, containing a Malus mandshurica extract as an active ingredient. The Malus mandshurica extract, which is an active ingredient of the present invention, has the effect of reducing the number of inflammatory...

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Bibliographische Detailangaben
Hauptverfasser:	WOO YOUNG JEON, MEEYOUNG LEE, EUN JIN SHON, SOO JIN JEONG, JINHEE KIM, JIHYE BANG, JIN SEONG EUN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	FODDER FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The present invention relates to a composition for preventing, alleviating or treating asthma, containing a Malus mandshurica extract as an active ingredient. The Malus mandshurica extract, which is an active ingredient of the present invention, has the effect of reducing the number of inflammatory cells in an asthma animal model, reducing the IgE content in BALF (bronchoalveolar lavage fluid) and plasma of an asthma animal model, reducing the IL-13 content in BALF of an asthma animal model, reducing the hyperplasia of mucus-secreting cells and the amount of mucus due to infiltration of inflammatory cells in lung tissue or bronchial remodeling, and reducing the activity of β-hexosaminidase in mast cells induced by degranulation. Therefore, the composition can be usefully used as a material for a therapeutic agent for asthma or a health functional food for alleviating asthma. 본 발명은 털야광나무 추출물을 유효성분으로 함유하는 천식의 예방, 개선 또는 치료용 조성물에 관한 것으로, 본 발명의 유효성분인 털야광나무 추출물은 천식 동물모델에서 염증 세포 수를 감소시키고, 천식 동물모델의 BALF(기관지폐포세척액) 및 혈장에서 IgE 함량을 감소시키고, 천식 동물모델의 BALF 내 IL-13의 함량을 감소시키고, 폐 조직 내 염증 세포들의 침윤 또는 기관지 재형성으로 인한 점액분비 세포의 과형성 및 점액의 양을 감소시키며, 탈과립이 유도된 비만세포의 β-헥소사미니다아제의 활성을 감소시키는 효과가 있으므로, 천식의 치료제, 천식 개선용 건강기능식품의 소재로 유용하게 사용될 수 있다.