API5 ANTIBODY SPECIFICALLY BINDING TO API5 PROTEIN

The present invention relates to an antibody specifically binding to an apoptosis inhibitor 5 (API5) protein and uses thereof. The antibody or an antigen-binding fragment thereof that specifically binds to the API5 according to the present invention can exhibit excellent anticancer effects, such as...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	RYOO JEONGMIN, SOHN JINYOUNG, YEOM JUNHO, YOON KYOUNG WAN, BOO KYUNGJIN, KIM SUJIN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to an antibody specifically binding to an apoptosis inhibitor 5 (API5) protein and uses thereof. The antibody or an antigen-binding fragment thereof that specifically binds to the API5 according to the present invention can exhibit excellent anticancer effects, such as inhibiting ERK phosphorylation in cancer cells and suppressing cancer growth. In addition, the antibody or antigen-binding fragment thereof exhibits excellent anticancer effects against cancers that are resistant or refractory to anticancer drugs, and is therefore, can be utilized effectively for prevention or treatment of not only general cancers, but also cancers that are resistant or refractory to the anticancer drugs. 본 발명은 API5(Apoptosis inhibitor 5)에 특이적으로 결합하는 항체 및 이의 용도에 관한 것이다. 본 발명에 따른 API5에 특이적으로 결합하는 항체 또는 이의 항원 결합 단편은 암세포의 ERK 인산화를 억제하고, 암의 성장을 억제하는 등의 우수한 항암 효과를 나타낼 수 있다. 또한, 상기 항체 또는 이의 항원 결합 단편은 항암제에 내성 또는 불응성을 나타내는 암에 대하여 우수한 항암 효과를 나타내는바, 일반적인 암뿐만 아니라, 항암제에 내성 또는 불응성을 나타내는 암의 예방 또는 치료 용도로도 유용하게 활용될 수 있다.