Pharmaceutical composition for the prevention or treatment of nervous system diseases containing a herbal mixture containing Astragalus

The present invention relates to a pharmaceutical composition for preventing or treating nervous system diseases, which contains, as an active ingredient, a mixture of Curcuma Longa Linne, Astragalus membranaceus Bunge, Brassica oleracea var. italica Plenck, Camellia sinensis (L.) O. Kuntze, Cirsium...

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Bibliographische Detailangaben
Hauptverfasser:	PARK SEONG IL, CHOI SEONG HWAN, YOO HO RYONG, KIM HYEONG GEUG
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The present invention relates to a pharmaceutical composition for preventing or treating nervous system diseases, which contains, as an active ingredient, a mixture of Curcuma Longa Linne, Astragalus membranaceus Bunge, Brassica oleracea var. italica Plenck, Camellia sinensis (L.) O. Kuntze, Cirsium japonicum var. ussuriense Kitamura, and Piper nigrum. The present invention provides a pharmaceutical composition for preventing or treating nervous system diseases, which enables GR to attenuate neuronal apoptosis using HT-22 cells and to reduce both of NO and ROS in LPS-stimulated BV-2 cells in cell-based test tube experiments. Moreover, the pharmaceutical composition can rapidly protect against neuronal damage, especially inflammatory response and oxidation, in the hippocampal region of LPS-induced mouse brain tissue by inactivating a target to JNK and an upstream signaling pathway of MKK7 and pc-Jun to regulate Sestrin protein in an animal experiment. 본 발명은 강황(Curcuma Longa Linne), 황기(Astragalus membranaceus Bunge), 브로콜리(Brassica oleracea var. italica Plenck), 녹다엽(Camellia sinensis (L.) O. Kuntze), 엉겅퀴(Cirsium japonicum var. ussuriense Kitamura) 및 호초(Piper nigrum)의 혼합물을 유효성분으로 함유하는 신경계 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로서, 본 발명의 신경계 질환의 예방 또는 치료용 약학적 조성물은 세포 기반 시험관 실험에서 GR은 HT-22 세포를 사용하여 신경 세포 사멸을 약화시키고 LPS로 자극된 BV-2 세포에서 NO와 ROS를 모두 감소시킬 수 있다. 또한, 동물 실험에서 JNK에 대한 표적과 MKK7 및 pc-Jun의 상류 신호 전달 경로를 비활성화하여 Sestrin 단백질을 조절함으로써 LPS 유도 마우스 뇌 조직의 해마 영역에서 신경 손상, 특히 염증 반응 및 산화를 신속하게 보호할 수 있다.