Inflammatory bowel disease patient immune system simulation avatar model and drug screening platform

The present invention relates to an avatar model for simulating an immune system of an inflammatory bowel disease patient, and a drug screening platform, and it was confirmed that in the avatar model for simulating the inflammatory bowel disease of the present invention, human immune cells in the blood effectively engraft, induce the development of the inflammatory bowel disease and damage to intestinal tissue, and effectively reflect the patient's disease state. Additionally, compared to PBMC injection from normal people, when PBMC from patients with the inflammatory bowel disease was injected, it was confirmed that the inflammatory bowel disease develops and that the inflammatory bowel disease can be improved by treatment with candidate substances, confirming that it is possible to screen for a customized therapeutic agent for patients. 본 발명은 염증성장질환 환자 면역 시스템 모사 아바타 모델과 약물 스크리닝 플랫폼에 관한 것으로서, 본 발명의 염증성 장질환 모사 아바타모델은, 혈액 내 인간 면역세포가 효과적으로 생착하며, 염증성 장질환의 발달 및 장조직의 손상을 유도하여, 환자의 질병 상태를 효과적으로 반영하는 것을 확인하였다. 또한, 정상인의 PBMC 주입과 비교하여, 염증성 장질환 환자의 PBMC를 주입하였을 때, 염증성 장질환이 발달되며, 후보물질의 처리로 염증성 장질환을 개선시킬 수 있는 것을 확인하여, 환자 맞춤형 치료제를 스크리닝 할 수 있는 것을 확인하였다.