(6R,10S)-10-{4-[5-클로로-2-(4-클로로-1H-1,2,3-트리아졸-1-일)페닐]-6-옥소-1(6H)-피리미디닐}-1-피라졸로[4,3-B][1,7]디아자시클로테트라데신-5(6H)-온을 제조하는 방법

본 출원은 일반적으로 (6R,10S)-10-{4-[5-클로로-2-(4-클로로-1H-1,2,3-트리아졸-1-일)페닐]-6-옥소-1(6H)-피리미디닐}-1-(디플루오로메틸)-6-메틸-1,4,7,8,9,10-헥사히드로-11,15-(메테노)피라졸로[4,3-b][1,7]디아자시클로테트라데신-5(6H)-온의 여러 제조 방법에 관한 것이다: TIFFpct00144.tif104130 The present application generally relates to several processes for the preparation of (6R,10...

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Hauptverfasser: SKLIAR DIMITRI, JUSSEAU XAVIER JEAN MARIE, LUO HELEN Y, PEREGO LUCA ALESSANDRO, BROGGINI DIEGO FERNANDO DOMENICO, XIOURAS CHRISTOS, RAHMANI RAMDANE, EASTGATE MARTIN D, CHERNICHENKO KOSTIANTYN, MUKHERJEE SUBHA, JAMISON CHRISTOPHER ROBERT, SFOUGGATAKIS CHRIS, WAGSCHAL SIMON ALBERT, GALLAGHER WILLIAM P, KOLOTUCHIN SERGEI, LEMAIRE SEBASTIEN FRANCOIS EMMANUEL, MATCHA KIRAN, WEI CAROLYN S, CAO DUY CHI TRUNG, REUTER KARL, ZHDANKO ALEXANDER, TRAN NGOC DUC, CUNIERE NICOLAS, SINGH AMARJIT, MOWER MATTHEW PENFIELD, WISNIEWSKI STEVEN R, KOSCHKER PHILIPP, ZHENG BIN, ORTIZ ADRIAN, BEN HAIM CYRIL, SCHMALZBAUER BJOERN
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Sprache:kor
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Zusammenfassung:본 출원은 일반적으로 (6R,10S)-10-{4-[5-클로로-2-(4-클로로-1H-1,2,3-트리아졸-1-일)페닐]-6-옥소-1(6H)-피리미디닐}-1-(디플루오로메틸)-6-메틸-1,4,7,8,9,10-헥사히드로-11,15-(메테노)피라졸로[4,3-b][1,7]디아자시클로테트라데신-5(6H)-온의 여러 제조 방법에 관한 것이다: TIFFpct00144.tif104130 The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one: Compound (I).