C3b -C5 ANTI-C3b ANTIBODY OR ANTI-C5 ANTIBODY CONJUGATED WITH ANGIOGENESIS INHIBITOR AND USE THEREOF

The present invention relates to a fusion protein comprising an anti-C3b antibody or an anti-C5 antibody and an angiogenesis inhibitor, and a composition using the same for treating eye diseases, specifically macular degeneration. The protein not only inhibits complement-related pathways but can als...

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Bibliographische Detailangaben
Hauptverfasser:	KIM DONGGEON, CHUNG EU DDEUM, RYU SOOMIN, CHANG JIHOON, LEE BYOUNG CHUL
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a fusion protein comprising an anti-C3b antibody or an anti-C5 antibody and an angiogenesis inhibitor, and a composition using the same for treating eye diseases, specifically macular degeneration. The protein not only inhibits complement-related pathways but can also efficiently regulate angiogenesis. Therefore, the fusion protein dimer can be effectively used in the treatment and prevention of complement-related diseases, specifically eye diseases such as macular degeneration, and has high potential for industrial use. 본 발명은 항-C3b 항체 또는 항-C5 항체 및 혈관신생 억제제를 포함하는 융합단백질 및 이를 이용한 안질환, 구체적으로 황반변성 치료용 조성물에 관한 것이다. 상기 단백질은 보체 관련 경로를 억제할 뿐 아니라 신생혈관생성을 효율적으로 조절할 수 있다. 따라서, 상기 융합단백질 이량체는 보체 관련 질환, 구체적으로 황반변성과 같은 안질환의 치료 및 예방에 효과적으로 활용할 수 있어 산업적 활용 가능성이 높다.