Composition for preventing improving or treating Parkinson's disease comprising enzyme hydrolysate of silkworm

The present invention relates to a composition for preventing, improving, or treating Parkinson's disease comprising an enzyme decomposition product of mature silkworms as an active ingredient. According to the present invention, it has been identified that the life expectancy and the healthy lifespan of fruit flies fed with an enzyme decomposition product of mature silkworms increase and the enzyme decomposition product of mature silkworms affects the expression of genes involved in Parkinson's disease-related signaling pathway. In addition, it has been identified that the average lifespan of fruit flies treated with rotenone, which is known as the cause of Parkinson's disease, increases, the activity of a mitochondrial complex increases and the effect is significantly superior to that of the mature silkworms, thereby enabling the enzyme decomposition product of the mature silkworms according to the present invention to be usefully used for prevention, improvement or treatment of Parkinson's disease. 본 발명은 홍잠 효소분해물을 유효성분으로 포함하는 파킨슨병 예방, 개선 또는 치료용 조성물에 대한 것으로, 본 발명에 따르면 홍잠 효소분해물을 급여한 초파리의 기대수명과 건강수명이 증대되었으며, 상기 홍잠 효소분해물은 파킨슨병 관련 신호전달경로에 연관된 유전자들의 발현에 영향을 미침을 확인하였다. 더불어 파킨슨병의 발병 원인으로 알려진 로테논이 처리된 초파리의 평균수명을 증대시켰고 미토콘드리아 복합체의 활성을 증대시켰으며, 그 효과가 홍잠 대비 월등히 우수함을 확인한 바, 본 발명에 따른 홍잠 효소분해물은 파킨슨병 예방, 개선 또는 치료를 위하여 유용하게 활용될 수 있다.