Composition for preventing or treating rheumatoid arthritis comprising Pinellia ternata Wolfiporia extensa Magnolia Officinalis Perilla frutescens var. acuta and Zingiber officinale as active ingredients

The present invention relates to a pharmaceutical composition and health functional foods for preventing or treating rheumatoid arthritis including a complex extract of Pinellia ternata, Wolfiporia extensa, Magnolia officinalis, Perilla frutescens and Zingiber officinale as an active ingredient. The...

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Bibliographische Detailangaben
Hauptverfasser: KWON HYUN SOOK, JEON YEONG HEE, RA CHAE SUK, KIM JUNG OK, LEEM HYUN HEE, SON SU MI, KIM SE JIN, NAM WON HEE
Format: Patent
Sprache:eng ; kor
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Zusammenfassung:The present invention relates to a pharmaceutical composition and health functional foods for preventing or treating rheumatoid arthritis including a complex extract of Pinellia ternata, Wolfiporia extensa, Magnolia officinalis, Perilla frutescens and Zingiber officinale as an active ingredient. The complex extract containing Pinellia ternata, Wolfiporia extensa, Magnolia officinalis, Perilla frutescens and Zingiber officinale according to the present invention has the activity of inhibiting proliferation and migration of synoviocyte lines, and inhibiting an expression or production of inflammatory cytokines IL-6, IL-1β, TNF-α, CCL2, and CXCL2. In addition, the complex extract is a complex extract derived from natural herbal medicine and has no side effects to be usefully used in manufacturing medicines and health functional foods for effectively preventing, alleviating, and treating rheumatoid arthritis. 본 발명은 반하, 복령, 후박, 자소엽 및 생강의 복합 추출물을 유효성분으로 포함하는 류마티스 관절염의 예방 또는 치료용 약학적 조성물 및 건강기능식품에 관한 것으로, 본 발명에 따른 반하, 복령, 후박, 자소엽 및 생강을 포함하여 구성된 복합 추출물은 활막세포주의 증식 및 이동 억제, 염증성 사이토카인인 IL-6, IL-1β, TNF-α, CCL2 및 CXCL2의 발현 또는 생성 억제 활성을 모두 가지고 있으며, 천연생약재 유래의 복합 추출물로서 부작용이 없기에 류마티스 관절염을 효과적으로 예방, 개선 및 치료하기 위한 의약품 및 건강기능식품의 제조에 유용하게 사용할 수 있다.