COMPOSITION FOR PREVENTING OR IMPROVING ORAL DISEASES COMPRISING AN EXTRACT OF SAUSSUREA NEOSERRATA

The present invention relates to a composition for preventing and alleviating oral diseases, wherein when a Saussurea neoserrata extract is contained as an active ingredient, there is no concern about side effects from long-term use due to the use of natural products; in a periodontal disease-induce...

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1. Verfasser: HYUN KYUNG YAE
Format: Patent
Sprache:eng ; kor
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Zusammenfassung:The present invention relates to a composition for preventing and alleviating oral diseases, wherein when a Saussurea neoserrata extract is contained as an active ingredient, there is no concern about side effects from long-term use due to the use of natural products; in a periodontal disease-induced model, contents of IL-1β, TNF-α, and MDA in the gingival tissue are reduced, osteoclast formation is reduced, and periodontal bone mass is increased; and through a reduction in the total aerobic viable cell count in oral isthmuses in a periodontal disease-induced model, saliva secretion is improved while showing activity in preventing or alleviating periodontal diseases so as to alleviate mouth dryness. Accordingly, the present invention can be effective in preventing or alleviating oral diseases including periodontal diseases and mouth dryness. 본 발명은 구강질환의 예방 또는 개선용 조성물에 관한 것으로, 산골취 추출물을 유효성분으로 포함하는 경우, 천연물을 이용함에 따라 장기간 복용에 따른 부작용의 우려가 없으며, 치주질환 유도 모델에서의 치은조직내 IL-1β, TNF-α 및 MDA 함량 감소, 파골세포 형성 감소 활성, 치주골량 증가 활성 및 치주질환 유도 모델에서의 구강 협부 총 호기성 생균수 감소를 통해 치주질환 예방 또는 개선 활성을 나타내면서도 타액 분비량을 향상시켜 구강건조증을 개선할 수 있어 치주질환 및 구강건조증을 포함하는 구강질환 예방 또는 개선 활성을 나타낼 수 있다.