aryl or heteroaryl derivatives and pharmaceutical composition thereof for use in preventing or treating kinase-related disease

The present invention relates to an aryl or heteroaryl derivative, and a pharmaceutical composition containing the same as an active ingredient for the treatment of a kinase-related disease. In one aspect of the present invention, the aryl or heteroaryl derivative exhibits excellent inhibitory activ...

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Bibliographische Detailangaben
Hauptverfasser:	KIM NAMDOO, MA DAHOON, PARK YESEUL, SIM GYUSEOK, JO SEOHYUN, SON JUNGBEOM, KIM SUNGHWAN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to an aryl or heteroaryl derivative, and a pharmaceutical composition containing the same as an active ingredient for the treatment of a kinase-related disease. In one aspect of the present invention, the aryl or heteroaryl derivative exhibits excellent inhibitory activity against kinases, especially receptor-interacting serine/threonine-protein kinase 1 (RIPK1), and can be used as a treatment for RIPK1-related diseases. 본 발명은, 아릴 또는 헤테로아릴 유도체, 및 이를 유효성분으로 포함하는 키나아제 관 련 질환 치료용 약학적 조성물에 관한 것으로, 본 발명의 일 측면에서 제공하는 아릴 또는 헤테로아릴 유도체는 키나아제, 특히 RIPK1(Receptor-interacting serine/threonine-protein kinase 1)에 대해 우수한 억제 활성을 나타내므로, RIPK1 관련 질환의 치료제로 사용 가능하다.