Novel imidazole derivatives having protein kinase Inhibitory activity and use thereof

The present invention relates to a novel imidazole derivative compound, an isomer thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same. The imidazole derivative compound according to the present invention exhibits selective inhibitory activity a...

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Bibliographische Detailangaben
Hauptverfasser:	JUN JOON HONG, BAEK JI HYUN, HAH JUNG MI
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a novel imidazole derivative compound, an isomer thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same. The imidazole derivative compound according to the present invention exhibits selective inhibitory activity against JNK, particularly JNK3, and is used as a pharmaceutical composition for preventing and treating degenerative brain diseases (degenerative brain diseases including Alzheimer's dementia and Parkinson's disease). 본 발명은 신규 이미다졸 유도체 화합물, 이의 이성질체 또는 이의 약학적으로 허용 가능한 염 및 이를 포함하는 약학적 조성물에 관한 것이다. 본 발명에 따른 이미다졸 유도체 화합물은 JNK, 특히 JNK3에 대해 선택적으로 저해 활성을 나타내어 퇴행성 뇌질환 (알츠하이머성 치매성 치매, 파킨슨 질환을 포함하는 퇴행성 뇌질환)의 예방 및 치료용 약학적 조성물로 이용될 수 있다.