PLK1 Novel PLK1 Protein Degradation Inducing Compounds

The present invention relates to a compound inducing PLK1 proteolysis and uses thereof. Since compounds of the present invention target a polo-box domain of PLK1 and degrade PLK1 with high selectivity, compounds can be very usefully used for preventing or treating PLK1-related diseases. 본 발명은 PLK1 단...

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Bibliographische Detailangaben
Hauptverfasser:	KEUM YOUNG KANG, HYE GUK RYU, SANG YOUN KIM, IM SUK MIN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a compound inducing PLK1 proteolysis and uses thereof. Since compounds of the present invention target a polo-box domain of PLK1 and degrade PLK1 with high selectivity, compounds can be very usefully used for preventing or treating PLK1-related diseases. 본 발명은 PLK1 단백질 분해 유도 화합물 및 이의 용도에 관한 것이다. 본 발명의 화합물들은 PLK1의 폴로-박스 도메인을 표적으로 하여 높은 선택성으로 PLK1을 분해하므로, PLK1 관련 질환의 예방 또는 치료 용도로 매우 유용하게 사용될 수 있다.