Sustained-release formulation composition comprising semaglutide or pharmaceutically acceptable salt thereof

The present invention relates to sustained-release microspheres containing semaglutide or a pharmaceutically acceptable salt thereof and a sustained-release formulation composition comprising same, which enable long-term sustained release of the drug without an initial burst, have no lag phase, and...

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Bibliographische Detailangaben
Hauptverfasser: CHO JAE PYOUNG, LEE JI HYANG, CHOI HO IL, JANG EUN SEO, CHANG SEUNG GU
Format: Patent
Sprache:eng ; kor
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Zusammenfassung:The present invention relates to sustained-release microspheres containing semaglutide or a pharmaceutically acceptable salt thereof and a sustained-release formulation composition comprising same, which enable long-term sustained release of the drug without an initial burst, have no lag phase, and have excellent bioavailability. 본 발명은 약물의 초기 과다 방출(initial burst)이 없고 장기간 지속 방출이 가능하면서도, 방출 지연(Lag phase)이 없고 생체이용률이 우수한, 세마글루타이드(semaglutide) 또는 이의 약학적으로 허용가능한 염을 포함하는 서방형 미립구 및 이를 포함하는 서방형 제제 조성물에 관한 것이다.