1--6- Composition for preventing improving or treating degenerative arthritis comprising steamed ginger extract or 1-dehydro-6-gingerdione isolated therefrom as an active ingredient

The present invention relates to a composition for preventing, alleviating, or treating degenerative arthritis comprising a steamed ginger extract or 1-dehydro-6-gingerdione isolated therefrom as an active ingredient. The steamed ginger extract according to the present invention or 1-dehydro-6-ginge...

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Bibliographische Detailangaben
Hauptverfasser: KANG TONG HO, PARK JAE HYUN, KWON JEONG EUN, JEONG YONG JOON, KIM IN HYE, LEE YEONG GEUN, YANG YOON JUNG, KIM TAE WOO, JEON HYELIN, KANG SE CHAN, PARK DAE WON, KIM EUN JEONG
Format: Patent
Sprache:eng ; kor
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Zusammenfassung:The present invention relates to a composition for preventing, alleviating, or treating degenerative arthritis comprising a steamed ginger extract or 1-dehydro-6-gingerdione isolated therefrom as an active ingredient. The steamed ginger extract according to the present invention or 1-dehydro-6-gingerdione isolated therefrom exhibits an effect of inhibiting inflammatory cytokine expression, cartilage tissue recovery, cartilage production, or cartilage degradation, and inhibits the expression of I-κB or NF-κB protein involved in inflammatory cytokine and MMP production, and thus is expected to be effectively used in functional food compositions, pharmaceutical compositions, or the like for preventing, alleviating, or treating degenerative arthritis. 본 발명은 증숙생강 추출물 또는 이로부터 분리된 1-데하이드로-6-진저다이온을 유효성분으로 포함하는 퇴행성 관절염 예방, 개선, 또는 치료용 조성물에 관한 것으로서, 본 발명에 따른 증숙생강 추출물 또는 이로부터 분리된 1-데하이드로-6-진저다이온은 염증성 사이토카인 발현 억제, 연골 조직 회복, 연골 생성, 또는 연골 분해 억제 효과를 나타내며, 염증성 사이토카인 및 MMP 생성에 관여하는 I-κB 또는 NF-κB 단백질의 발현을 억제하는 바, 퇴행성 관절염을 예방, 개선, 또는 치료하기 위한 기능성 식품 조성물, 약학적 조성물 등에 유용하게 이용될 것으로 기대된다.