NUCLEOSIDE DERIVATIVE HAVING KINASE MULTIPLE TARGET INHIBITING ACTIVITY AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING CANCER COMPRISING THE SAME

The present invention relates to a nucleoside derivative which can be used for preventing or treating cancer by inhibiting kinases, and a pharmaceutical composition containing the same. The nucleoside derivative has inhibitory activity against kinases such as NTRK1, CSNK1D, DYRK1A, DYRK1B and FLT3,...

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Bibliographische Detailangaben
Hauptverfasser:	YUM YUN A, SUSHIL KUMAR TRIPATHI, LEE SANG KOOK, KWON JEE YOUN, SUNG KI SU, KARISHMA K. MASHELKAR, JEONG LAK SHIN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The present invention relates to a nucleoside derivative which can be used for preventing or treating cancer by inhibiting kinases, and a pharmaceutical composition containing the same. The nucleoside derivative has inhibitory activity against kinases such as NTRK1, CSNK1D, DYRK1A, DYRK1B and FLT3, and thus exhibits inhibitory activity against various cancer cells directly or indirectly related to kinases. Therefore, the nucleoside derivative can be used to prevent or treat various cancers such as lung cancer, colon cancer, breast cancer, liver cancer, gastric cancer and prostate cancer. 본 발명은 인산화효소를 저해함으로써 암 예방 또는 치료에 사용될 수 있는 뉴클레오사이드 유도체 및 이를 포함하는 약학적 조성물에 관한 것으로서, 상기 뉴클레오사이드 유도체는 NTRK1, CSNK1D, DYRK1A, DYRK1B 및 FLT3와 같은 인산화효소들에 대해 저해 활성을 가지며, 이에 따라 인산화효소와 직간접적으로 연관된 다양한 암세포에 대한 저해 활성을 나타내기 때문에, 폐암, 결장암, 유방암, 간암, 위암 및 전립선암 등의 각종 암을 예방 또는 치 치료하는데 사용될 수 있다.