E-N'-3--2--2-4--34H- Novel E-N'-3-allyl-2-hydroxybenzylidene-2-4-oxoquinazolin-34H-ylacetohydrazides and an anticancer composition comprising the same as an active ingredient

The present invention relates to an (E)-N'-(3-allyl-2-hydroxy)benzylidene-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazide compound and an anticancer agent composition comprising the same as an active ingredient. Specifically, the (E)-N'-(3-allyl-2-hydroxy)benzylidene-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazide compound according to the present invention activates procaspase-3 and promotes conversion to caspase-3, so as to be used as a proliferation inhibitor for various cancer cells. The compound according to the present invention is expected to be developed as an active ingredient of a potent anticancer agent. 본 발명은 (E)-N'-(3-알릴-2-히드록시)벤질리덴-2-(4-옥소퀴나졸린-3(4H)-일)아세토히드라지드 화합물 및 이를 유효성분으로 포함하는 항암제 조성물에 관한 것이다. 구체적으로, 본 발명에 따른 (E)-N'-(3-알릴-2-히드록시)벤질리덴-2-(4-옥소퀴나졸린-3(4H)-일)아세토히드라지드 화합물은 프로카스파제-3를 활성화하여 카스파제-3으로의 전환을 촉진하므로, 다양한 암세포에 대한 증식억제제로 사용될 수 있다. 본 발명에 따른 화합물은 강력한 항암제의 활성성분으로서 개발될 수 있을 것으로 기대된다.