2 Composition for enhancing immune anticancer effect comprising an alpha 2 adrenergic receptor agonist
The present invention relates to an anti-cancer effect enhancing composition comprising an alpha-2 adrenergic receptor agonist as an active ingredient. More specifically, by confirming the enhancement of anti-cancer effects in which cancer cell-derived exosome secretion is inhibited and PD-L1 expres...
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| Format: | Patent |
| Sprache: | eng ; kor |
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| Zusammenfassung: | The present invention relates to an anti-cancer effect enhancing composition comprising an alpha-2 adrenergic receptor agonist as an active ingredient. More specifically, by confirming the enhancement of anti-cancer effects in which cancer cell-derived exosome secretion is inhibited and PD-L1 expression inducing immune escape of T cells is inhibited when treating a cancer cell with the composition according to the present invention, the alpha-2 adrenergic receptor agonist may be utilized for developing an anti-cancer effect enhancing formulation for enhancing prevention or treatment of cancer, as an immune checkpoint inhibitor or an inhibitor against cell surface or exosome PD-L1 expression.
본 발명은 알파-2 아드레날린 수용체 효능제를 유효성분으로 포함하는 항암 효과 증진용 조성물에 관한 것으로, 보다 상세하게는 본 발명에 따른 조성물을 암세포에 처리하였을 때에 암세포 유래의 엑소좀 분비가 억제되고, T 세포의 면역 회피를 유도하는 PD-L1의 발현이 억제되는 항암효과가 증진되는 것을 확인함으로써, 알파-2 아드레날린 수용체 효능제를 면역관문 억제제 및 세포 표면 또는 엑소좀 PD-L1의 발현에 대한 억제제로써 암 질환의 예방 또는 치료를 증진할 수 있는 항암 효과 증진용 제제 개발에 유용하게 활용될 수 있다. |
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