Composition for preventing or treating mitochondrial dysfunctiondiseases containing isoquinoline derivative compound as an active ingredient

The present invention relates to a composition for preventing or treating diseases caused by mitochondrial dysfunction, containing an isoquinoline derivative compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient. The composition does not ind...

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Bibliographische Detailangaben
Hauptverfasser:	JONG HYUN CHO, SEMYEONG CHOI, DONG JIN SHIN, JEANHO YUN, JEE HYUN UM
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The present invention relates to a composition for preventing or treating diseases caused by mitochondrial dysfunction, containing an isoquinoline derivative compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient. The composition does not induce mitochondrial damage like conventional mitochondrial toxins such as CCCP, and specifically and excellently promotes the activity of mitophagy to alleviate mitochondrial abnormalities, and thus can be usefully used for the treatment of diseases caused by mitochondrial dysfunction. 본 발명은 화학식 1로 표시되는 이소퀴놀린 유도체 화합물 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 미토콘드리아 기능이상으로 인한 질환의 예방 또는 치료용 조성물에 관한 것으로서, 종래의 CCCP 등의 미토콘드리아 독소들 (mitochondrial toxins)과 같이 미토콘드리아의 손상을 유도하지 않고, 미토파지의 활성을 특이적이고, 우수하게 촉진하여 미토콘드리아 이상을 개선할 수 있는 바, 미토콘드리아 기능이상으로 인한 질환의 치료에 유용하게 사용할 수 있다.