SARS-CoV-2 Novel triazolyl combretastain derivatives and composition for prevention or treatment of coronavirus SARS-CoV-2infection diseases containing the same as active ingredients

The present invention relates to a novel triazolyl combretastatin derivative and a composition containing the same as an active ingredient for prevention or treatment of corona virus infection disease. The novel triazolyl combretastatin derivative of the present invention exhibits an excellent inhib...

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Bibliographische Detailangaben
Hauptverfasser:	JI MI BAEK, YOUNGSEON CHOI, SHIN WOON SEOB, LEE SEOK JOON
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The present invention relates to a novel triazolyl combretastatin derivative and a composition containing the same as an active ingredient for prevention or treatment of corona virus infection disease. The novel triazolyl combretastatin derivative of the present invention exhibits an excellent inhibitory effect on infection of severe acute respiratory syndrome virus-2 (SARS-CoV-2) through a novel mechanism, and a manufacturing method therefor is simple. Thus, the derivative can be advantageously used in a composition for preventing and treating virus infection, particularly for preventing, inhibiting, and treating coronavirus disease-19 (COVID-19) caused by SARS-CoV-2. 본 발명은 신규 트리아졸릴 콤브레타스타틴 유도체 및 이를 유효성분으로 함유하는 코로나 바이러스 감염 질환의 예방 또는 치료용 조성물로서, 본 발명의 신규한 트리아졸릴 콤브레타스타틴 유도체는 새로운 기전에 기하여 제2형 중증급성호흡기 증후군 바이러스 (SARS-CoV-2) 감염에 대한 우수한 억제 효과를 발휘할 뿐 아니라, 제조 공정도 비교적 간단하여 바이러스감염증 예방 및 치료, 특히 제2형 중증급성호흡기 증후군 바이러스 감염에 의한 코로나바이러스감염증-19 예방, 억제, 및 치료 조성물로 유용하게 사용될 수 있다.