[15-a] Imidazo[15-a]pyrazine derivative compounds and pharmaceutical compositions for use in preventing or treating cancer or autoimmune disease containing the same as active ingredients

The present invention relates to a novel imidazo[1,5-a]pyrazine derivative compound, a stereoisomer thereof, a hydrate thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for preventing or treating cancer or autoimmune diseases containing the same as an active co...

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Bibliographische Detailangaben
Hauptverfasser:	PARK JEONG EUN, KIM SHINAE, JOO JEONGMIN, KIM KYUNG HEE, LEE SUN JOO, JUNG KYUNGJIN, JEON YONG HYUN, MOON HEEGYUM, CHIN JUNGWOOK, KIM JINA, KWON SUGYEONG
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The present invention relates to a novel imidazo[1,5-a]pyrazine derivative compound, a stereoisomer thereof, a hydrate thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for preventing or treating cancer or autoimmune diseases containing the same as an active component, wherein the imidazo[1,5-a]pyrazine derivative compound provided in the present invention exhibits high selectivity and inhibitory activity against Bruton's tyrosine kinase (BTK), thereby being able to be usefully used for preventing or treating BTK-related diseases. 본 발명은 신규한 이미다조[1,5-a]피라진 유도체 화합물, 이의 입체 이성질체, 이의 수화물, 또는 이의 약학적으로 허용 가능한 염, 및 이를 유효성분으로 함유하는 암 또는 자가면역질환의 예방 또는 치료를 위한 약학적 조성물에 관한 것으로, 상기 본 발명에서 제공하는 이미다조[1,5-a]피라진 유도체 화합물은 BTK(Bruton's tyrosine kinase)에 대하여 높은 선택성 및 억제능을 나타내므로 BTK 관련 질환의 예방 또는 치료에 유용하게 사용될 수 있다.