Animal model of anxiety disorder due to chronic social isolation method for manufacturing and use thereof

The present invention relates to an anxiety disorder animal model due to chronic social isolation, a method for manufacturing the same, and a use thereof. The animal model according to the present invention reproduces aspects of anxiety disorder induced by social isolation or chronic social stress t...

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Bibliographische Detailangaben
Hauptverfasser: KO JAE WON, YOON TAEK HAN, UM JI WON, PARK DONG SEOK
Format: Patent
Sprache:eng ; kor
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Zusammenfassung:The present invention relates to an anxiety disorder animal model due to chronic social isolation, a method for manufacturing the same, and a use thereof. The animal model according to the present invention reproduces aspects of anxiety disorder induced by social isolation or chronic social stress through knockout of an LRRTM3 gene in the prefrontal cortex of the brain, so that it is expected to be useful for the provision of knowledge related to anxiety disorders caused by chronic social isolation or stress, the development of biomarkers for diagnosis and treatment, and the development of treatments for anxiety disorders. 본 발명은 만성적 사회적 고립에 의한 불안장애 동물 모델, 이의 제조방법 및 이의 용도에 관한 것이다. 본 발명에 따른 동물 모델은 뇌의 전전두엽에서 LRRTM3 유전자의 넉아웃을 통해 사회적 고립 또는 사회적 만성 스트레스에 의해 유발되는 불안장애 양상을 재현한 것으로서, 상기와 같은 만성적 사회적 고립 또는 스트레스에 의해 유발되는 불안장애의 관련 지식 제공, 진단 및 치료를 위한 바이오마커 개발, 불안장애 치료제 개발 등에 유용하게 활용 가능할 것으로 기대된다.