Particle comprising chitosan-bilirubin conjugate and Pharmaceutical composition comprising the same

The present invention relates to chitosan-bilirubin conjugates, particles, and pharmaceutical compositions comprising the same. The conjugate and/or particle of the present invention has excellent antioxidant and anti-inflammatory effects, relieves intestinal inflammatory reactions as well as reliev...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WHANG CHANG HEE, RAHMAN AFIA TASNIM, JON SANGYONG
Format: Patent
Sprache:eng ; kor
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Beschreibung
Zusammenfassung:The present invention relates to chitosan-bilirubin conjugates, particles, and pharmaceutical compositions comprising the same. The conjugate and/or particle of the present invention has excellent antioxidant and anti-inflammatory effects, relieves intestinal inflammatory reactions as well as relieves systemic inflammation, and has an effect of normalizing the balance of intestinal microbial distribution, thereby being able to be usefully used for treating inflammatory bowel disease, and systemic and chronic inflammatory diseases. 본 발명은 키토산-빌리루빈 접합체, 입자, 및 이를 포함하는 약제학적 조성물에 관한 것이다. 본 발명의 접합체 및/또는 입자는 항산화 효능 및 항염증 효능이 우수하며, 장내 염증반응의 완화 뿐만 아니라, 전신 염증의 완화 효과를 나타내며, 장내 미생물 분포의 균형을 정상화시키는 효능이 있으므로, 염증성 장질환, 전신성, 만성염증성 질환 등의 치료에 유용하게 사용할 수 있다.