NT-814의 핵심 중간체인 6-클로로-4-피리딘-3-아민의 새로운 화학적 제조 방법

본 발명은 화합물 2-[3,5-비스(트리플루오로메틸)페닐]-N-{4-(4-플루오로-2-메틸페닐)-6-[(7S,9aS)-7-(히드록시메틸)헥사히드로피라지노[2,1-c][1,4]옥사진-8(1H)-일]-3-피리디닐}-N,2-디메틸프로판아미드 (화합물 A)의 제조에 유용한 화합물 2-(3,5-비스(트리플루오로메틸)페닐)-N-(6-클로로-4-(4-플루오로-2-메틸페닐)피리딘-3-일)-N,2-디메틸프로판아미드 (화합물 IX)의 새로운 제조 방법에 관한 것이다. The invention relates to a new process for pro...

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Bibliographische Detailangaben
Hauptverfasser:	GHIZZONI MASSIMO, SCHLEUSNER MARCEL, LAWRENCE RON
Format:	Patent
Sprache:	kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	본 발명은 화합물 2-[3,5-비스(트리플루오로메틸)페닐]-N-{4-(4-플루오로-2-메틸페닐)-6-[(7S,9aS)-7-(히드록시메틸)헥사히드로피라지노[2,1-c][1,4]옥사진-8(1H)-일]-3-피리디닐}-N,2-디메틸프로판아미드 (화합물 A)의 제조에 유용한 화합물 2-(3,5-비스(트리플루오로메틸)페닐)-N-(6-클로로-4-(4-플루오로-2-메틸페닐)피리딘-3-일)-N,2-디메틸프로판아미드 (화합물 IX)의 새로운 제조 방법에 관한 것이다. The invention relates to a new process for producing compound 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide (Compound IX) which is useful in the manufacture of compound 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide (Compound A).